Whole Genome Constitution Testing Explanation:
The critical information related to human life processes, health, and disease resides within the genomes of both the cell nucleus and mitochondria. Nuclear information is stored in approximately 3 billion base pairs of complementary DNA strands, while mitochondrial information is contained in around 17,000 base pairs. These base pair variations vary significantly among individuals. In terms of the nuclear genome, there are approximately 4-5 million base pair variants, and each individual may also have nearly 100 unique, non-heritable base variations. These variations shape each person’s constitution, individual responses to environmental changes, and distinctive aging and health patterns. Therefore, to accurately predict, prevent, diagnose, and treat health issues or diseases, it is essential to understand the specific variations in each base pair within the nuclear and mitochondrial genomes.
How can we understand each individual’s nuclear and mitochondrial base variations? This requires genome sequencing technology. In the past, due to the high cost and complexity of genome analysis and interpretation, sequencing focused only on disease-associated or protein-coding bases (whole exome sequencing) and was generally applied to diagnose genetic disorders. However, in the last few years, the cost, speed, and interpretive capacity of genome sequencing have greatly advanced, making whole genome sequencing the preferred method for precision health and disease diagnosis.
Our company uses the latest genome sequencing technology and the most precise, rapid interpretation tools, integrating our proprietary database with existing public data sources to deliver highly accurate analyses of individual genome variations.
Currently, genome sequencing and analysis results only enable precise predictions of present or future disease-related variations without offering effective prevention or treatment options. Over the past few years, our research team has actively investigated the relationship between herbal medicine and gene function, developing methods that leverage herbal medicine to precisely address individual genetic weaknesses or defects for preventive health and disease management. Even when genetic abnormalities are present, herbal medicine can be employed to treat related diseases arising from these genetic variations.
Target Audience for Whole Genome Constitution Testing:
1. Healthy individuals seeking a precise understanding of their constitution and potential future health risks.
2. Family members of individuals with hereditary diseases or cancer.
3. Individuals with a hereditary disease of unknown genetic origin.
4. Individuals with rare diseases with no family history of inheritance.
5. Individuals with various refractory conditions with poor treatment outcomes.
Constitution Tracking (Using Transcriptome or Expression Profiling) Testing Explanation:
The essential information for human life is encoded within the genome, and this genomic information undergoes complex regulatory mechanisms to transcribe DNA into RNA (transcriptome or expression profile), which is then translated into proteins that perform the necessary functions for cellular health, growth, and aging. Thus, transcriptome analysis provides insights into the real-time dynamics of genome function. When the body is influenced by environmental changes, medications, or lifestyle factors, epigenomic alterations occur within the genome, resulting in varying transcriptomic profiles. Through precise transcriptome analysis, we can assess whether genome function is operating normally and monitor the impacts of environmental factors, medications, or lifestyle on genome functionality. These influences cascade from the genomic level to cells, tissues, organs, and systems, ultimately affecting individual health. Therefore, transcriptome analysis offers valuable real-time information about an individual’s health status. Human white blood cells express more than 50% of genomic information and can be obtained through blood sampling, making them an ideal testing material. Our company collects data from public databases and has established a series of refined analytical methods. These tools, in addition to assessing genome function and medication response, also provide health-related analyses tailored to client needs.
Target Audience for Constitution Tracking (Using Transcriptome or Expression Profiling) Testing:
1. Healthy individuals actively engaged in health maintenance, seeking insights into its effectiveness.
2. Individuals with hereditary diseases or carriers wishing to understand the effects of treatment or preventive therapy.
3. Individuals with rare or difficult-to-treat conditions who wish to evaluate treatment effectiveness or adjust medications.
